Anti-E2F2 antibody (C-Term) (STJ118795)

SKU:
STJ118795

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-E2F2 (C-Term) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: E2F2
Gene ID: 1870
Uniprot ID: E2F2_HUMAN
Immunogen Region: C-Term
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 300 to the C-terminus of human E2F2 (NP_004082.1).
Immunogen Sequence: VYLCPEEVQEPDSPSEEPLP STSTLCPSPDSAQPSSSTDP SIMEPTASSVPAPAPTPQQA PPPPSLVPLEATDSLLELPH PLLQQTEDQFLSPTLACSSP LISFSPSLDQDDYLWGLEAG EGISDLFDSYDLGDLLIN
Tissue Specificity Highest level of expression is found in placenta, low levels are found in lung. Found as well in many immortalized cell lines derived from tumor samples.
Post Translational Modifications Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase.
Function Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from g1 to s phase. E2F2 binds specifically to RB1 in a cell-cycle dependent manner.
Protein Name Transcription Factor E2f2
E2f-2
Database Links Reactome: R-HSA-2559580
Reactome: R-HSA-2559585
Reactome: R-HSA-69231
Reactome: R-HSA-9661069
Cellular Localisation Nucleus
Alternative Antibody Names Anti-Transcription Factor E2f2 antibody
Anti-E2f-2 antibody
Anti-E2F2 antibody

Information sourced from Uniprot.org

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