| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DYNLT1 (1-113) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DYNLT1 |
| Gene ID: |
6993 |
| Uniprot ID: |
DYLT1_HUMAN |
| Immunogen Region: |
1-113 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-113 of human DYNLT1 (NP_006510.1). |
| Immunogen Sequence: |
MEDYQAAEETAFVVDEVSNI VKEAIESAIGGNAYQHSKVN QWTTNVVEQTLSQLTKLGKP FKYIVTCVIMQKNGAGLHTA SSCFWDSSTDGSCTVRWENK TMYCIVSAFGLSI |
| Tissue Specificity | Expressed in heart, placenta, skeletal muscle kidney, pancreas, spleen, prostate, testis, ovary, ileum and colon. Expressed in lung endothelial and smooth muscle cells (at protein level). |
| Post Translational Modifications | Phosphorylated by BMPR2.the phosphorylation is abolished by BMPR2 mutations in exon 12 which lead to truncated forms of BMPR2 and which are linked to primary pulmonary hypertension (PPH1) MIM:178600. The phosphorylation status is proposed to regulate the association with the cytoplasmic dynein complex and may have role in cytoplasmic dynein cargo release. |
| Function | Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Binds to transport cargos and is involved in apical cargo transport such as rhodopsin-bearing vesicles in polarized epithelia. May also be a accessory component of axonemal dynein. Plays a role in neuronal morphogenesis.the function is independent of cytoplasmic dynein and seems to be coupled to regulation of the actin cytoskeleton by enhancing Rac1 activity. The function in neurogenesis may be regulated by association with a G-protein beta-gamma dimer. May function as a receptor-independent activator of heterotrimeric G-protein signaling.the activation appears to be independent of a nucleotide exchange. Plays a role in regulating neurogenesis.inhibits the genesis of neurons from precursor cells during cortical development presumably by antagonizing ARHGEF2. Involved in the regulation of mitotic spindle orientation. Unrelated to the role in retrograde microtubule-associated movement may play a role in the dimerization of cytoplasmic proteins/domains such as for ACVR2B. Binds to the cytoplasmic domain of ACVR2B and, in vitro, inhibits ACVR2B signaling. (Microbial infection) Is involved in intracellular targeting of D-type retrovirus gag polyproteins to the cytoplasmic assembly site. |
| Protein Name | Dynein Light Chain Tctex-Type 1Protein Cw-1T-Complex Testis-Specific Protein 1 Homolog |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Golgi ApparatusCytoplasmCytoskeletonSpindleLocalizes To Mitotic Spindles |
| Alternative Antibody Names | Anti-Dynein Light Chain Tctex-Type 1 antibodyAnti-Protein Cw-1 antibodyAnti-T-Complex Testis-Specific Protein 1 Homolog antibodyAnti-DYNLT1 antibodyAnti-TCTEL1 antibodyAnti-TCTEX-1 antibodyAnti-TCTEX1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
