Host: | Rabbit |
Applications: | WB/ELISA |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | DUSP6 |
Gene ID: | 1848 |
Uniprot ID: | DUS6_HUMAN |
Immunogen Region: | 302-381 |
Specificity: | Recombinant fusion protein containing a sequence within amino acids 302-381 of human DUSP6 (NP_001937.2). |
Immunogen Sequence: | TVTVAYLMQKLNLSMNDAYD IVKMKKSNISPNFNFMGQLL DFERTLGLSSPCDNRVPAQQ LYFTTPSNQNVYQVDSLQST |
Tissue Specificity | Expressed in keratinocytes (at protein level). |
Function | Inactivates MAP kinases. Has a specificity for the ERK family. Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia. Also important for dephosphorylation of MAPK1/3 in local wound tissue, which further contributes to resolution of acute pain. Promotes cell differentiation by regulating MAPK1/MAPK3 activity and regulating the expression of AP1 transcription factors. |
Protein Name | Dual Specificity Protein Phosphatase 6 Dual Specificity Protein Phosphatase Pyst1 Mitogen-Activated Protein Kinase Phosphatase 3 Map Kinase Phosphatase 3 Mkp-3 |
Database Links | Reactome: R-HSA-112409 Reactome: R-HSA-202670 Reactome: R-HSA-5675221 Reactome: R-HSA-9652817 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase 6 antibody Anti-Dual Specificity Protein Phosphatase Pyst1 antibody Anti-Mitogen-Activated Protein Kinase Phosphatase 3 antibody Anti-Map Kinase Phosphatase 3 antibody Anti-Mkp-3 antibody Anti-DUSP6 antibody Anti-MKP3 antibody Anti-PYST1 antibody |
Information sourced from Uniprot.org