| Tissue Specificity | Ubiquitously expressed, with highest levels in testis, placenta, prostate, muscle and brain. |
| Function | Dipeptidyl peptidase that cleaves off N-terminal dipeptides from proteins having a Pro or Ala residue at position 2. Acts as a key inhibitor of caspase-1-dependent monocyte and macrophage pyroptosis in resting cells by preventing activation of NLRP1 and CARD8. Sequesters the cleaved C-terminal part of NLRP1 and CARD8, which respectively constitute the active part of the NLRP1 and CARD8 inflammasomes, in a ternary complex, thereby preventing their oligomerization and activation. The dipeptidyl peptidase activity is required to suppress NLRP1 and CARD8.however, neither NLRP1 nor CARD8 are bona fide substrates of DPP8, suggesting the existence of substrate(s) required for NLRP1 and CARD8 inhibition. |
| Protein Name | Dipeptidyl Peptidase 8Dp8Dipeptidyl Peptidase Iv-Related Protein 1Dprp-1Dipeptidyl Peptidase ViiiDpp ViiiProlyl Dipeptidase Dpp8 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Dipeptidyl Peptidase 8 antibodyAnti-Dp8 antibodyAnti-Dipeptidyl Peptidase Iv-Related Protein 1 antibodyAnti-Dprp-1 antibodyAnti-Dipeptidyl Peptidase Viii antibodyAnti-Dpp Viii antibodyAnti-Prolyl Dipeptidase Dpp8 antibodyAnti-DPP8 antibodyAnti-DPRP1 antibodyAnti-MSTP097 antibodyAnti-MSTP135 antibodyAnti-MSTP141 antibody |
Information sourced from Uniprot.org
