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Anti-DNM2 antibody (607-866) (STJ23410)

Immunofluorescence analysis of PC-12 cells using DNM2 antibody (STJ23410) at dilution of 1:150. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of NIH/3T3 cells using DNM2 antibody (STJ23410) at dilution of 1:150. Blue: DAPI for nuclear staining.
Immunofluorescence analysis of U2OS cells using DNM2 antibody (STJ23410) at dilution of 1:150. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using DNM2 antibody (STJ23410) at 1:500 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.

Anti-DNM2 antibody (607-866) (STJ23410)

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STJ23410

£112.50 - £522.50

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General Information
Product Properties
Target Information
Additional Info
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Host:	Rabbit
Applications:	WB/IF
Reactivity:	Human/Mouse/Rat
Note:	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description:	Rabbit polyclonal antibody anti-DNM2 (607-866) is suitable for use in Western Blot and Immunofluorescence research applications.

Clonality:	Polyclonal
Conjugation:	Unconjugated
Isotype:	IgG
Formulation:	PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification:	Affinity purification
Dilution Range:	WB 1:500-1:2000 IF/ICC 1:50-1:200
Storage Instruction:	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol:	DNM2
Gene ID:	1785
Uniprot ID:	DYN2_HUMAN
Immunogen Region:	607-866
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 607-866 of human DNM2 (NP_004936.2).
Immunogen Sequence:	EDVDSWKASFLRAGVYPEKD QAENEDGAQENTFSMDPQLE RQVETIRNLVDSYVAIINKS IRDLMPKTIMHLMINNTKAF IHHELLAYLYSSADQSSLME ESADQAQRRDDMLRMYHALK EALNIIGDISTSTVSTPVPP PVDDTWLQSASSHSPTPQRR PVSSIHPPGRPPAVRGPTPG PPLIPVPVGAAASFSAPPIP SRPGPQSVFANSDLFPAPPQ IPSRPVRIPPGIPPGVPSR

Tissue Specificity	Ubiquitously expressed.
Post Translational Modifications	Phosphorylation at Ser-764 by CDK1 is greatly increased upon mitotic entry. It regulates cytokinesis downstream of calcineurin, and does not affect clathrin-mediated endocytosis. Dephosphorylated by calcineurin/PP2. Phosphorylated on tyrosine residues after activation of SRC.
Function	Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones. Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis. Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane.
Protein Name	Dynamin-2
Database Links	Reactome: R-HSA-166016 Reactome: R-HSA-177504 Reactome: R-HSA-190873 Reactome: R-HSA-196025 Reactome: R-HSA-203641 Reactome: R-HSA-2132295 Reactome: R-HSA-432720 Reactome: R-HSA-432722 Reactome: R-HSA-437239 Reactome: R-HSA-8856828 Reactome: R-HSA-9031628
Cellular Localisation	Cytoplasm Cytoskeleton Cell Junction Membrane Clathrin-Coated Pit Postsynaptic Density Synapse Midbody Cell Projection Phagocytic Cup Cytoplasmic Vesicle Phagosome Membrane Peripheral Membrane Protein Colocalizes With Cttn At The Basis Of Filopodia In Hippocampus Neuron Growth Zones Microtubule-Associated Also Found In The Postsynaptic Density Of Neuronal Cells Co-Localizes With Pik3c3 And Rab5a To The Nascent Phagosome
Alternative Antibody Names	Anti-Dynamin-2 antibody Anti-DNM2 antibody Anti-DYN2 antibody

Information sourced from Uniprot.org

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