| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
DLG5 |
| Gene ID: |
9231 |
| Uniprot ID: |
DLG5_HUMAN |
| Immunogen Region: |
1436-1701 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1436-1701 of human DLG5 (NP_004738.3). |
| Immunogen Sequence: |
SHSRSSSHLDPAGTHSTLQG SGTTTPEHPSVIDPLMEQDE GPSTPPAKQSSSRIAGDANK KTLEPRVVFIKKSQLELGVH LCGGNLHGVFVAEVEDDSPA KGPDGLVPGDLILEYGSLDV RNKTVEEVYVEMLKPRDGVR LKVQYRPEEFTKAKGLPGDS FYIRALYDRLADVEQELSFK KDDILYVDDTLPQGTFGSWM AWQLDENAQKIQRGQIPSKY VMDQEFSRRLSMSEVKDDN |
| Tissue Specificity | Highly expressed in normal breast tissues and low-grade breast cancer tissues (at protein level). Highly expressed in the placenta and prostate. Expressed at a lower level in the thyroid, spinal cord, trachea, adrenal gland, skeletal muscle, pancreas, heart, brain, liver and kidney. A short splice product shows more limited expression, being absent from at least the brain. |
| Function | Acts as a regulator of the Hippo signaling pathway. Negatively regulates the Hippo signaling pathway by mediating the interaction of MARK3 with STK3/4, bringing them together to promote MARK3-dependent hyperphosphorylation and inactivation of STK3 kinase activity toward LATS1. Positively regulates the Hippo signaling pathway by mediating the interaction of SCRIB with STK4/MST1 and LATS1 which is important for the activation of the Hippo signaling pathway. Involved in regulating cell proliferation, maintenance of epithelial polarity, epithelial-mesenchymal transition (EMT), cell migration and invasion. Plays an important role in dendritic spine formation and synaptogenesis in cortical neurons.regulates synaptogenesis by enhancing the cell surface localization of N-cadherin. Acts as a positive regulator of hedgehog (Hh) signaling pathway. Plays a critical role in the early point of the SMO activity cycle by interacting with SMO at the ciliary base to induce the accumulation of KIF7 and GLI2 at the ciliary tip for GLI2 activation. |
| Protein Name | Disks Large Homolog 5Discs Large Protein P-DlgPlacenta And Prostate Dlg |
| Database Links | Reactome: R-HSA-9013420Reactome: R-HSA-9013424Reactome: R-HSA-9696264Reactome: R-HSA-9696270Reactome: R-HSA-9696273 |
| Cellular Localisation | Cell JunctionCell MembranePeripheral Membrane ProteinPostsynaptic DensityCytoplasmCytoskeletonCilium Basal BodyLocalized At Sites Of Cell-Cell Contact |
| Alternative Antibody Names | Anti-Disks Large Homolog 5 antibodyAnti-Discs Large Protein P-Dlg antibodyAnti-Placenta And Prostate Dlg antibodyAnti-DLG5 antibodyAnti-KIAA0583 antibodyAnti-PDLG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
