| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DIXDC1 |
| Gene ID: | 85458 |
| Uniprot ID: | DIXC1_HUMAN |
| Immunogen Region: | 173-472 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 173-472 of human DIXDC1 (NP_219493.1). |
| Immunogen Sequence: | SVLQLKQELLRANMDKDELH NQNVDLQRKLDERNRLLGEY KKELGQKDRLLQQHQAKLEE ALRKLSDVSYHQVDLERELE HKDVLLAHCMKREADEATNY NSHNSQSNGFLLPTAGKGAT SVSNRGTSDLQLVRDALRSL RNSFSGHDPQHHTIDSLEQG ISSLMERLHVMETQKKQERK VRVKSPRTQVGSEYRESWPP NSKLPHSQSSPTVSSTCTKV LYFTDRSLTPFMVNIPKRL |
| Tissue Specificity | Ubiquitously expressed with higher expression in cardiac and skeletal muscles. |
| Post Translational Modifications | Phosphorylated on tyrosine and serine residues. Polyubiquitinated, leading to its proteasomal degradation. WNT3A signaling increases DIXDC1 protein levels by inhibiting its ubiquitination and subsequent degradation. |
| Function | Positive effector of the Wnt signaling pathway.activates WNT3A signaling via DVL2. Regulates JNK activation by AXIN1 and DVL2. |
| Protein Name | DixinCoiled-Coil Protein Dix1Coiled-Coil-Dix1Dix Domain-Containing Protein 1 |
| Cellular Localisation | Cell JunctionFocal AdhesionCytoplasmCytoskeletonStress FiberColocalizes With Gamma-Tubulin At The CentrosomeBoth During Interphase And MitosisAssociated With Actin Stress Fiber At The Filament EndsIsoform 2: CytoplasmNot Associated With Stress Fibers |
| Alternative Antibody Names | Anti-Dixin antibodyAnti-Coiled-Coil Protein Dix1 antibodyAnti-Coiled-Coil-Dix1 antibodyAnti-Dix Domain-Containing Protein 1 antibodyAnti-DIXDC1 antibodyAnti-CCD1 antibodyAnti-KIAA1735 antibody |
Information sourced from Uniprot.org