| Function | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics. Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function. Involved in the reduction of all-trans-retinal to all-trans-retinol. Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable. Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group. A dehydrogenase activity has not been detected so far. May play a role as tumor suppressor. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 7Retinal Short-Chain Dehydrogenase/Reductase 4Retsdr4Short Chain Dehydrogenase/Reductase Family 34c Member 1Protein Sdr34c1 |
| Cellular Localisation | Endoplasmic Reticulum MembraneBound To The Endoplasmic Reticulum MembranePossibly Through A N-Terminus AnchorThe Main Bulk Of The Polypeptide Chain Was First Reported To Be Facing Toward The Lumen Of The Endoplasmic ReticulumHoweverIt Was Later Shown To Be Facing The Cytosol |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 7 antibodyAnti-Retinal Short-Chain Dehydrogenase/Reductase 4 antibodyAnti-Retsdr4 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 34c Member 1 antibodyAnti-Protein Sdr34c1 antibodyAnti-DHRS7 antibodyAnti-DHRS7A antibodyAnti-RETSDR4 antibodyAnti-SDR34C1 antibodyAnti-CGI-86 antibodyAnti-UNQ285 antibodyAnti-PRO3448 antibody |
Information sourced from Uniprot.org
