| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DHRS7 |
| Gene ID: | 51635 |
| Uniprot ID: | DHRS7_HUMAN |
| Immunogen Region: | 1-339 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human DHRS7 (NP_057113.1). |
| Immunogen Sequence: | MNWELLLWLLVLCALLLLLV QLLRFLRADGDLTLLWAEWQ GRRPEWELTDMVVWVTGASS GIGEELAYQLSKLGVSLVLS ARRVHELERVKRRCLENGNL KEKDILVLPLDLTDTGSHEA ATKAVLQEFGRIDILVNNGG MSQRSLCMDTSLDVYRKLIE LNYLGTVSLTKCVLPHMIER KQGKIVTVNSILGIISVPLS IGYCASKHALRGFFNGLRTE LATYPGIIVSNICPGPVQS |
| Tissue Specificity | Found predominantly in the adrenal glands, liver, thyroid, prostate, small intestine, colon, stomach, kidney and brain. Lower levels observed in skeletal muscle, the lung and the spleen. |
| Function | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics. Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function. Involved in the reduction of all-trans-retinal to all-trans-retinol. Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable. Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group. A dehydrogenase activity has not been detected so far. May play a role as tumor suppressor. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 7 Retinal Short-Chain Dehydrogenase/Reductase 4 Retsdr4 Short Chain Dehydrogenase/Reductase Family 34c Member 1 Protein Sdr34c1 |
| Cellular Localisation | Endoplasmic Reticulum Membrane Bound To The Endoplasmic Reticulum Membrane Possibly Through A N-Terminus Anchor The Main Bulk Of The Polypeptide Chain Was First Reported To Be Facing Toward The Lumen Of The Endoplasmic Reticulum However It Was Later Shown To Be Facing The Cytosol |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 7 antibody Anti-Retinal Short-Chain Dehydrogenase/Reductase 4 antibody Anti-Retsdr4 antibody Anti-Short Chain Dehydrogenase/Reductase Family 34c Member 1 antibody Anti-Protein Sdr34c1 antibody Anti-DHRS7 antibody Anti-DHRS7A antibody Anti-RETSDR4 antibody Anti-SDR34C1 antibody Anti-CGI-86 antibody Anti-UNQ285 antibody Anti-PRO3448 antibody |
Information sourced from Uniprot.org