| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DHRS7 (1-339) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DHRS7 |
| Gene ID: |
51635 |
| Uniprot ID: |
DHRS7_HUMAN |
| Immunogen Region: |
1-339 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-339 of human DHRS7 (NP_057113.1). |
| Immunogen Sequence: |
MNWELLLWLLVLCALLLLLV QLLRFLRADGDLTLLWAEWQ GRRPEWELTDMVVWVTGASS GIGEELAYQLSKLGVSLVLS ARRVHELERVKRRCLENGNL KEKDILVLPLDLTDTGSHEA ATKAVLQEFGRIDILVNNGG MSQRSLCMDTSLDVYRKLIE LNYLGTVSLTKCVLPHMIER KQGKIVTVNSILGIISVPLS IGYCASKHALRGFFNGLRTE LATYPGIIVSNICPGPVQS |
| Tissue Specificity | Found predominantly in the adrenal glands, liver, thyroid, prostate, small intestine, colon, stomach, kidney and brain. Lower levels observed in skeletal muscle, the lung and the spleen. |
| Function | NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including steroids, retinoids and xenobiotics. Catalyzes the reduction/inactivation of 5alpha-dihydrotestosterone to 3alpha-androstanediol, with a possible role in the modulation of androgen receptor function. Involved in the reduction of all-trans-retinal to all-trans-retinol. Converts cortisone to 20beta-dihydrocortisone in vitro, although the physiological relevance of this activity is questionable. Reduces exogenous compounds such as quinones (1,2-naphtoquinone, 9,10-phenantrenequinone and benzoquinone) and other xenobiotics (alpha-diketones) in vitro, suggesting a role in the biotransformation of xenobiotics with carbonyl group. A dehydrogenase activity has not been detected so far. May play a role as tumor suppressor. |
| Protein Name | Dehydrogenase/Reductase Sdr Family Member 7Retinal Short-Chain Dehydrogenase/Reductase 4Retsdr4Short Chain Dehydrogenase/Reductase Family 34c Member 1Protein Sdr34c1 |
| Cellular Localisation | Endoplasmic Reticulum MembraneBound To The Endoplasmic Reticulum MembranePossibly Through A N-Terminus AnchorThe Main Bulk Of The Polypeptide Chain Was First Reported To Be Facing Toward The Lumen Of The Endoplasmic ReticulumHoweverIt Was Later Shown To Be Facing The Cytosol |
| Alternative Antibody Names | Anti-Dehydrogenase/Reductase Sdr Family Member 7 antibodyAnti-Retinal Short-Chain Dehydrogenase/Reductase 4 antibodyAnti-Retsdr4 antibodyAnti-Short Chain Dehydrogenase/Reductase Family 34c Member 1 antibodyAnti-Protein Sdr34c1 antibodyAnti-DHRS7 antibodyAnti-DHRS7A antibodyAnti-RETSDR4 antibodyAnti-SDR34C1 antibodyAnti-CGI-86 antibodyAnti-UNQ285 antibodyAnti-PRO3448 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
