| Tissue Specificity | Widely expressed. Most abundant in adrenal gland, liver, testis, and brain. |
| Function | Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation. |
| Protein Name | 7-Dehydrocholesterol Reductase7-Dhc ReductaseDelta7-Sterol ReductaseSterol Delta(7-ReductaseSterol Reductase Sr-2 |
| Database Links | Reactome: R-HSA-2426168Reactome: R-HSA-6807047Reactome: R-HSA-6807062 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-7-Dehydrocholesterol Reductase antibodyAnti-7-Dhc Reductase antibodyAnti-Delta7-Sterol Reductase antibodyAnti-Sterol Delta(7-Reductase antibodyAnti-Sterol Reductase Sr-2 antibodyAnti-DHCR7 antibodyAnti-D7SR antibody |
Information sourced from Uniprot.org
