| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DHCR7 |
| Gene ID: |
1717 |
| Uniprot ID: |
DHCR7_HUMAN |
| Immunogen Region: |
346-475 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human DHCR7 (NP_001351.2). |
| Immunogen Sequence: |
VGYYIFRVANHQKDLFRRTD GRCLIWGRKPKVIECSYTSA DGQRHHSKLLVSGFWGVARH FNYVGDLMGSLAYCLACGGG HLLPYFYIIYMAILLTHRCL RDEHRCASKYGRDWERYTAA VPYRLLPGIF |
| Tissue Specificity | Widely expressed. Most abundant in adrenal gland, liver, testis, and brain. |
| Function | Catalyzes the last step of the cholesterol synthesis pathway, which transforms cholesta-5,7-dien-3beta-ol (7-dehydrocholesterol,7-DHC) into cholesterol by reducing the C7-C8 double bond of its sterol core. Can also metabolize cholesta-5,7,24-trien-3beta-ol (7-dehydrodemosterol, 7-DHD) to desmosterol, which is then metabolized by the Delta(24)-sterol reductase (DHCR24) to cholesterol. Modulates ferroptosis (a form of regulated cell death driven by iron-dependent lipid peroxidation) through the metabolic breakdown of the anti-ferroptotic metabolites 7-DHC and 7-DHD which, when accumulated, divert the propagation of peroxyl radical-mediated damage from phospholipid components to its sterol core, protecting plasma and mitochondrial membranes from phospholipid autoxidation. |
| Protein Name | 7-Dehydrocholesterol Reductase7-Dhc ReductaseDelta7-Sterol ReductaseSterol Delta(7-ReductaseSterol Reductase Sr-2 |
| Database Links | Reactome: R-HSA-2426168Reactome: R-HSA-6807047Reactome: R-HSA-6807062 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-7-Dehydrocholesterol Reductase antibodyAnti-7-Dhc Reductase antibodyAnti-Delta7-Sterol Reductase antibodyAnti-Sterol Delta(7-Reductase antibodyAnti-Sterol Reductase Sr-2 antibodyAnti-DHCR7 antibodyAnti-D7SR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
