| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DGKQ (683-942) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DGKQ |
| Gene ID: |
1609 |
| Uniprot ID: |
DGKQ_HUMAN |
| Immunogen Region: |
683-942 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 683-942 of human DGKQ (NP_001338.2). |
| Immunogen Sequence: |
GRVLRWGAGYSGEDPFSVLL SVDEADAVLMDRWTILLDAH EAGSAENDTADAEPPKIVQM SNYCGIGIDAELSLDFHQAR EEEPGKFTSRLHNKGVYVRV GLQKISHSRSLHKQIRLQVE RQEVELPSIEGLIFINIPSW GSGADLWGSDSDTRFEKPRM DDGLLEVVGVTGVVHMGQVQ GGLRSGIRIAQGSYFRVTLL KATPVQVDGEPWVQAPGHMI ISAAGPKVHMLRKAKQKPR |
| Post Translational Modifications | Phosphorylated by PRKCE and PRKCH in vitro. |
| Function | Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Within the adrenocorticotropic hormone signaling pathway, produces phosphatidic acid which in turn activates NR5A1 and subsequent steroidogenic gene transcription. Also functions downstream of the nerve growth factor signaling pathway being specifically activated in the nucleus by the growth factor. Through its diacylglycerol activity also regulates synaptic vesicle endocytosis. |
| Protein Name | Diacylglycerol Kinase ThetaDag Kinase ThetaDgkthetaDiglyceride Kinase ThetaDgk-Theta |
| Database Links | Reactome: R-HSA-114508 |
| Cellular Localisation | CytoplasmCytosolCell MembraneSynapseCytoskeletonNucleusNucleus SpeckleNucleus MatrixTranslocates To The Plasma Membrane In Response To Steroid Hormone Receptor StimulationTranslocation To The Plasma Membrane Is Dependent On G-Protein Coupled Receptor Stimulation And Subsequent Activation Of Prkce And Probably PrkchTranslocates To The Nucleus In Response To Thrombin Stimulation (Probable)Association With The Nuclear Matrix Is Regulated By Nerve Growth Factor |
| Alternative Antibody Names | Anti-Diacylglycerol Kinase Theta antibodyAnti-Dag Kinase Theta antibodyAnti-Dgktheta antibodyAnti-Diglyceride Kinase Theta antibodyAnti-Dgk-Theta antibodyAnti-DGKQ antibodyAnti-DAGK4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
