| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DGAT2 |
| Gene ID: |
84649 |
| Uniprot ID: |
DGAT2_HUMAN |
| Immunogen Region: |
289-388 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 289-388 of human DGAT2 (NP_115953.2). |
| Immunogen Sequence: |
IFEEGSWGRWVQKKFQKYIG FAPCIFHGRGLFSSDTWGLV PYSKPITTVVGEPITIPKLE HPTQQDIDLYHTMYMEALVK LFDKHKTKFGLPETEVLEVN |
| Tissue Specificity | Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin. |
| Function | Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation. In liver, is primarily responsible for incorporating endogenously synthesized fatty acids into triglycerides. Functions also as an acyl-CoA retinol acyltransferase (ARAT). Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG). |
| Protein Name | Diacylglycerol O-Acyltransferase 2Acyl-Coa Retinol O-Fatty-AcyltransferaseAratRetinol O-Fatty-AcyltransferaseDiglyceride Acyltransferase 2 |
| Database Links | Reactome: R-HSA-1482883Reactome: R-HSA-75109 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLipid DropletCytoplasmPerinuclear Region |
| Alternative Antibody Names | Anti-Diacylglycerol O-Acyltransferase 2 antibodyAnti-Acyl-Coa Retinol O-Fatty-Acyltransferase antibodyAnti-Arat antibodyAnti-Retinol O-Fatty-Acyltransferase antibodyAnti-Diglyceride Acyltransferase 2 antibodyAnti-DGAT2 antibodyAnti-HMFN1045 antibodyAnti-UNQ738 antibodyAnti-PRO1433 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
