| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | DET1 |
| Gene ID: | 55070 |
| Uniprot ID: | DET1_HUMAN |
| Immunogen Region: | 15-240 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 15-240 of human DET1 (NP_060466.2). |
| Immunogen Sequence: | HVSTIKPRRIQNQNVIHRLE RRRISSGKAGTHWHQVRVFH QNVFPNFTVVNVEKPPCFLR KFSPDGRYFIAFSSDQTSLE IYEYQGCQAAEDLLQGYEGE ILSNGNDQRSVNIRGRLFER FFVLLHITNVAANGEHLNRE CSLFTDDCRCVIVGSAAYLP DEPHPPFFEVYRNSESVTPN PRSPLEDYSLHIIDLHTGRL CDTRTFKCDKVVLSHNQGLY LYKNIL |
| Tissue Specificity | Highly expressed in the ovary, some lymphoid organs and resting leukocytes. |
| Function | Component of the E3 ubiquitin ligase DCX DET1-COP1 complex, which is required for ubiquitination and subsequent degradation of target proteins. The complex is involved in JUN ubiquitination and degradation. |
| Protein Name | Det1 HomologDe-Etiolated-1 Homolog |
| Database Links | Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Det1 Homolog antibodyAnti-De-Etiolated-1 Homolog antibodyAnti-DET1 antibody |
Information sourced from Uniprot.org