| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-DERL1 (182-251) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DERL1 |
| Gene ID: |
79139 |
| Uniprot ID: |
DERL1_HUMAN |
| Immunogen Region: |
182-251 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 182-251 of human DERL1 (NP_077271.1). |
| Immunogen Sequence: |
LYFFLMFRYPMDLGGRNFLS TPQFLYRWLPSRRGGVSGFG VPPASMRRAADQNGGGGRHN WGQGFRLGDQ |
| Tissue Specificity | Ubiquitous. |
| Function | Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. Forms homotetramers which encircle a large channel traversing the endoplasmic reticulum (ER) membrane. This allows the retrotranslocation of misfolded proteins from the ER into the cytosol where they are ubiquitinated and degraded by the proteasome. The channel has a lateral gate within the membrane which provides direct access to membrane proteins with no need to reenter the ER lumen first. May mediate the interaction between VCP and the misfolded protein. Also involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. (Microbial infection) In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. |
| Protein Name | Derlin-1Degradation In Endoplasmic Reticulum Protein 1Dertrin-1Der1-Like Protein 1 |
| Database Links | Reactome: R-HSA-382556Reactome: R-HSA-532668Reactome: R-HSA-5678895Reactome: R-HSA-8866654 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Derlin-1 antibodyAnti-Degradation In Endoplasmic Reticulum Protein 1 antibodyAnti-Dertrin-1 antibodyAnti-Der1-Like Protein 1 antibodyAnti-DERL1 antibodyAnti-DER1 antibodyAnti-UNQ243 antibodyAnti-PRO276 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
