| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:200-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
DDO |
| Gene ID: |
8528 |
| Uniprot ID: |
OXDD_HUMAN |
| Immunogen Region: |
1-369 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-369 of human DDO (NP_003640.2). |
| Immunogen Sequence: |
MRPARHWETRFGARDFGGFQ DCFFRDRLMDTARIAVVGAG VVGLSTAVCISKLVPRCSVT IISDKFTPDTTSDVAAGMLI PHTYPDTPIHTQKQWFRETF NHLFAIANSAEAGDAGVHLV SGWQIFQSTPTEEVPFWADV VLGFRKMTEAELKKFPQYVF GQAFTTLKCECPAYLPWLEK RIKGSGGWTLTRRIEDLWEL HPSFDIVVNCSGLGSRQLAG DSKIFPVRGQVLQVQAPWV |
| Tissue Specificity | Expressed in epithelial cells of the proximal nephron tubules in the renal cortex (at protein level). In the brain, expressed in the frontal, temporal, and occipital lobes of the cortex, hippocampus, striatum, diencephalon, brainstem, cerebellum, spinal cord, plexus choroiderus and ependyma (at protein level). Expression is increased in the prefrontal cortex of schizophrenic patients. Levels are normal in the superior frontal gyrus of patients with Alzheimer's disease. |
| Post Translational Modifications | May be S-nitrosylated. |
| Function | Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors. Protects the organism from the toxicity of D-amino acids. May also function in the intestine. |
| Protein Name | D-Aspartate OxidaseDasoxDaspoDdo |
| Database Links | Reactome: R-HSA-389661Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome MatrixCytoplasmCytosolActive In The Peroxisomal MatrixIsoform Ddo-1: Peroxisome MatrixIsoform 3: Peroxisome Matrix |
| Alternative Antibody Names | Anti-D-Aspartate Oxidase antibodyAnti-Dasox antibodyAnti-Daspo antibodyAnti-Ddo antibodyAnti-DDO antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Western blot analysis of lysates from wild type (WT) and TWF2 knockout (KO) 293T cells, using [KO Validated] TWF2 Rabbit polyclonal antibody (STJ11100774) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/89710/358192/STJ11100774_1__12392.1713122508.jpg?c=1 "Western blot analysis of lysates from wild type (WT) and TWF2 knockout (KO) 293T cells, using [KO Validated] TWF2 Rabbit polyclonal antibody (STJ11100774) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.")
