| Tissue Specificity | Expressed in epithelial cells of the proximal nephron tubules in the renal cortex (at protein level). In the brain, expressed in the frontal, temporal, and occipital lobes of the cortex, hippocampus, striatum, diencephalon, brainstem, cerebellum, spinal cord, plexus choroiderus and ependyma (at protein level). Expression is increased in the prefrontal cortex of schizophrenic patients. Levels are normal in the superior frontal gyrus of patients with Alzheimer's disease. |
| Post Translational Modifications | May be S-nitrosylated. |
| Function | Selectively catalyzes the oxidative deamination of acidic amino acids. Suppresses the level of D-aspartate in the brain, an amino acid that can act as an agonist for glutamate receptors. Protects the organism from the toxicity of D-amino acids. May also function in the intestine. |
| Protein Name | D-Aspartate OxidaseDasoxDaspoDdo |
| Database Links | Reactome: R-HSA-389661Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome MatrixCytoplasmCytosolActive In The Peroxisomal MatrixIsoform Ddo-1: Peroxisome MatrixIsoform 3: Peroxisome Matrix |
| Alternative Antibody Names | Anti-D-Aspartate Oxidase antibodyAnti-Dasox antibodyAnti-Daspo antibodyAnti-Ddo antibodyAnti-DDO antibody |
Information sourced from Uniprot.org
