| Tissue Specificity | Expressed in brain, heart, kidney, liver, pancreas, placenta and skeletal muscle. |
| Function | May be required for DNA interstrand cross-link repair. Also required for checkpoint mediated cell cycle arrest in early prophase in response to mitotic spindle poisons. Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin. Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem). |
| Protein Name | Dna Cross-Link Repair 1a ProteinBeta-Lactamase Dclre1aSnm1 Homolog AHsnm1Hsnm1a |
| Database Links | Reactome: R-HSA-6783310 |
| Cellular Localisation | NucleusIn Some Cells It May Be Found In Typically 1 Or 2 Discrete Nuclear Aggregates Of Unknown Function Which Also Contain Tp53bp1Also Found In Multiple Discrete Nuclear Foci Which Increase In Number Following Treatment With Ionizing Radiation Or Interstrand Cross-Linking AgentsThese Foci Overlap With Those Formed By The Mrn Complex (Composed Of Mre11Rad50 And Nbn) And Brca1 |
| Alternative Antibody Names | Anti-Dna Cross-Link Repair 1a Protein antibodyAnti-Beta-Lactamase Dclre1a antibodyAnti-Snm1 Homolog A antibodyAnti-Hsnm1 antibodyAnti-Hsnm1a antibodyAnti-DCLRE1A antibodyAnti-KIAA0086 antibodyAnti-SNM1 antibodyAnti-SNM1A antibody |
Information sourced from Uniprot.org
