• Western blot analysis of extracts of mouse brain, using DCC antibody (STJ111681) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 300s.
  • Western blot analysis of lysates from Mouse brain, using DCC Rabbit polyclonal antibody (STJ111681) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 300s.

Anti-DCC antibody (1000-1100) (STJ111681)

SKU:
STJ111681

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Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DCC (1000-1100) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: DCC
Gene ID: 1630
Uniprot ID: DCC_HUMAN
Immunogen Region: 1000-1100
Immunogen: A synthetic peptide corresponding to a sequence within amino acids 1000-1100 of human DCC (NP_005206.2).
Immunogen Sequence: ISGDRLTHQIMDLNLDTMYY FRIQARNSKGVGPLSDPILF RTLKVEHPDKMANDQGRHGD GGYWPVDTNLIDRSTLNEPP IGQMHPPHGSVTPQKNSNLL V
Tissue Specificity Found in axons of the central and peripheral nervous system and in differentiated cell types of the intestine. Not expressed in colorectal tumor cells that lost their capacity to differentiate into mucus producing cells.
Post Translational Modifications Ubiquitinated.mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
Function Receptor for netrin required for axon guidance. Mediates axon attraction of neuronal growth cones in the developing nervous system upon ligand binding. Its association with UNC5 proteins may trigger signaling for axon repulsion. It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand. Implicated as a tumor suppressor gene.
Protein Name Netrin Receptor Dcc
Colorectal Cancer Suppressor
Immunoglobulin Superfamily Dcc Subclass Member 1
Tumor Suppressor Protein Dcc
Database Links Reactome: R-HSA-373752
Reactome: R-HSA-376172
Reactome: R-HSA-418885
Reactome: R-HSA-418886
Reactome: R-HSA-418889
Reactome: R-HSA-418890
Reactome: R-HSA-428542
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Netrin Receptor Dcc antibody
Anti-Colorectal Cancer Suppressor antibody
Anti-Immunoglobulin Superfamily Dcc Subclass Member 1 antibody
Anti-Tumor Suppressor Protein Dcc antibody
Anti-DCC antibody
Anti-IGDCC1 antibody

Information sourced from Uniprot.org

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