| Tissue Specificity | Liver. Also present in kidney: specifically expressed in the S2 and S3 segments of proximal tubules in cortex and outer medulla. |
| Function | A cytochrome P450 monooxygenase involved in the metabolism of various endogenous substrates, including fatty acids, eicosanoids and vitamins. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). Catalyzes predominantly the oxidation of the terminal carbon (omega-oxidation) of long- and very long-chain fatty acids. Displays high omega-hydroxylase activity toward polyunsaturated fatty acids (PUFAs). Participates in the conversion of arachidonic acid to omega-hydroxyeicosatetraenoic acid (20-HETE), a signaling molecule acting both as vasoconstrictive and natriuretic with overall effect on arterial blood pressure. Plays a role in the oxidative inactivation of eicosanoids, including both pro-inflammatory and anti-inflammatory mediators such as leukotriene B4 (LTB4), lipoxin A4 (LXA4), and several HETEs. Catalyzes omega-hydroxylation of 3-hydroxy fatty acids. Converts monoepoxides of linoleic acid leukotoxin and isoleukotoxin to omega-hydroxylated metabolites. Contributes to the degradation of very long-chain fatty acids (VLCFAs) by catalyzing successive omega-oxidations and chain shortening. Plays an important role in vitamin metabolism by chain shortening. Catalyzes omega-hydroxylation of the phytyl chain of tocopherols (forms of vitamin E), with preference for gamma-tocopherols over alpha-tocopherols, thus promoting retention of alpha-tocopherols in tissues. Omega-hydroxylates and inactivates phylloquinone (vitamin K1), and menaquinone-4 (MK-4, a form of vitamin K2), both acting as cofactors in blood coagulation. |
| Protein Name | Cytochrome P450 4f220-Hydroxyeicosatetraenoic Acid Synthase20-Hete SynthaseArachidonic Acid Omega-HydroxylaseCypivf2Cytochrome P450-Ltb-OmegaDocosahexaenoic Acid Omega-HydroxylaseLeukotriene-B(4 20-Monooxygenase 1Leukotriene-B(4 Omega-Hydroxylase 1Phylloquinone Omega-Hydroxylase Cyp4f2 |
| Database Links | Reactome: R-HSA-211935Reactome: R-HSA-211958Reactome: R-HSA-211979Reactome: R-HSA-2142691Reactome: R-HSA-2142816 |
| Cellular Localisation | Microsome MembranePeripheral Membrane ProteinEndoplasmic Reticulum Membrane |
| Alternative Antibody Names | Anti-Cytochrome P450 4f2 antibodyAnti-20-Hydroxyeicosatetraenoic Acid Synthase antibodyAnti-20-Hete Synthase antibodyAnti-Arachidonic Acid Omega-Hydroxylase antibodyAnti-Cypivf2 antibodyAnti-Cytochrome P450-Ltb-Omega antibodyAnti-Docosahexaenoic Acid Omega-Hydroxylase antibodyAnti-Leukotriene-B(4 20-Monooxygenase 1 antibodyAnti-Leukotriene-B(4 Omega-Hydroxylase 1 antibodyAnti-Phylloquinone Omega-Hydroxylase Cyp4f2 antibodyAnti-CYP4F2 antibody |
Information sourced from Uniprot.org
