| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CYP2W1 (141-490) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CYP2W1 |
| Gene ID: |
54905 |
| Uniprot ID: |
CP2W1_HUMAN |
| Immunogen Region: |
141-490 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 141-490 of human CYP2W1 (NP_060251.2). |
| Immunogen Sequence: |
EPVADKILQELKCLSGQLDG YRGRPFPLALLGWAPSNITF ALLFGRRFDYRDPVFVSLLG LIDEVMVLLGSPGLQLFNVY PWLGALLQLHRPVLRKIEEV RAILRTLLEARRPHVCPGDP VCSYVDALIQQGQGDDPEGL FAEANAVACTLDMVMAGTET TSATLQWAALLMGRHPDVQG RVQEELDRVLGPGRTPRLED QQALPYTSAVLHEVQRFITL LPHVPRCTAADTQLGGFLL |
| Tissue Specificity | Very low levels are detected in fetal and adult tissues. Highly expressed in several tumor samples, in particular colon and adrenal tumors. |
| Function | A cytochrome P450 monooxygenase that may play a role in retinoid and phospholipid metabolism. Catalyzes the hydroxylation of saturated carbon hydrogen bonds. Hydroxylates all trans-retinoic acid (atRA) to 4-hydroxyretinoate and may regulate atRA clearance. Other retinoids such as all-trans retinol and all-trans retinal are potential endogenous substrates. Catalyzes both epoxidation of double bonds and hydroxylation of carbon hydrogen bonds of the fatty acyl chain of 1-acylphospholipids/2-lysophospholipids. Can metabolize various lysophospholipids classes including lysophosphatidylcholines (LPCs), lysophosphatidylinositols (LPIs), lysophosphatidylserines (LPSs), lysophosphatidylglycerols (LPGs), lysophosphatidylethanolamines (LPEs) and lysophosphatidic acids (LPAs). Has low or no activity toward 2-acylphospholipids/1-lysophospholipids, diacylphospholipids and free fatty acids. May play a role in tumorigenesis by activating procarcinogens such as aflatoxin B1, polycyclic aromatic hydrocarbon dihydrodiols and aromatic amines. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR.NADPH-ferrihemoprotein reductase). |
| Protein Name | Cytochrome P450 2w1Cypiiw1 |
| Database Links | Reactome: R-HSA-211958Reactome: R-HSA-211981 |
| Cellular Localisation | Endoplasmic Reticulum LumenCell MembraneMicrosome MembraneAbout 8% Are Expressed On The Cell Surface |
| Alternative Antibody Names | Anti-Cytochrome P450 2w1 antibodyAnti-Cypiiw1 antibodyAnti-CYP2W1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
