| Background | This gene encodes a multi-pass membrane protein that belongs to the CXC chemokine receptor family. It is expressed in mature B-cells and Burkitt's lymphoma. This cytokine receptor binds to B-lymphocyte chemoattractant (BLC) , and is involved in B-cell migration into B-cell follicles of spleen and Peyer patches. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. |
| Tissue Specificity | Expression in mature B-cells and Burkitt lymphoma cells. |
| Function | Cytokine receptor that binds to B-lymphocyte chemoattractant (BLC). Involved in B-cell migration into B-cell follicles of spleen and Peyer patches but not into those of mesenteric or peripheral lymph nodes. May have a regulatory function in Burkitt lymphoma (BL) lymphomagenesis and/or B-cell differentiation. |
| Database Links | Reactome: R-HSA-380108 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Protein Name | C-X-C Chemokine Receptor Type 5Cxc-R5Cxcr-5Burkitt Lymphoma Receptor 1Monocyte-Derived Receptor 15Mdr-15Cd Antigen Cd185 |
| Alternative Names | Anti-C-X-C Chemokine Receptor Type 5 antibodyAnti-Cxc-R5 antibodyAnti-Cxcr-5 antibodyAnti-Burkitt Lymphoma Receptor 1 antibodyAnti-Monocyte-Derived Receptor 15 antibodyAnti-Mdr-15 antibodyAnti-Cd Antigen Cd185 antibodyAnti-CXCR5 antibodyAnti-BLR1 antibodyAnti-MDR15 antibody |
Information sourced from uniprot.org
