| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Casein Kinase I Isoform Epsilon (247-416) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CSNK1E |
| Gene ID: |
102800317/1454 |
| Uniprot ID: |
KC1E_HUMAN |
| Immunogen Region: |
247-416 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 247-416 of human CSNK1E (NP_689407.1). |
| Immunogen Sequence: |
EFSTYLNFCRSLRFDDKPDY SYLRQLFRNLFHRQGFSYDY VFDWNMLKFGAARNPEDVDR ERREHEREERMGQLRGSATR ALPPGPPTGATANRLRSAAE PVASTPASRIQPAGNTSPRA ISRVDRERKVSMRLHRGAPA NVSSSDLTGRQEVSRIPASQ TSVPFDHLGK |
| Tissue Specificity | Expressed in all tissues examined, including brain, heart, lung, liver, pancreas, kidney, placenta and skeletal muscle. Expressed in monocytes and lymphocytes but not in granulocytes. |
| Post Translational Modifications | Autophosphorylated. Partially dephosphorylated by PPP5C. May be dephosphorylated by PP1. |
| Function | Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (Probable). Participates in Wnt signaling. Phosphorylates DVL1. Phosphorylates DVL2. Phosphorylates NEDD9/HEF1. Central component of the circadian clock. In balance with PP1, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. Controls PER1 and PER2 nuclear transport and degradation. Inhibits cytokine-induced granuloytic differentiation. |
| Protein Name | Casein Kinase I Isoform EpsilonCki-EpsilonCkie |
| Database Links | Reactome: R-HSA-201688Reactome: R-HSA-2565942Reactome: R-HSA-380259Reactome: R-HSA-380270Reactome: R-HSA-380284Reactome: R-HSA-380320Reactome: R-HSA-400253Reactome: R-HSA-5620912Reactome: R-HSA-6791226Reactome: R-HSA-8854518 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Casein Kinase I Isoform Epsilon antibodyAnti-Cki-Epsilon antibodyAnti-Ckie antibodyAnti-CSNK1E antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunofluorescence analysis of HeLa cells using [KO Validated] CSNK1E Rabbit polyclonal antibody (STJ28096). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/101475/389282/STJ28096_1__59763.1713158942.jpg?c=1 "Immunofluorescence analysis of HeLa cells using [KO Validated] CSNK1E Rabbit polyclonal antibody (STJ28096). Secondary antibody: Cy3 Goat Anti-Rabbit IgG (H+L) at 1:500 dilution. Blue: DAPI for nuclear staining.")
