| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CORO1C |
| Gene ID: | 23603 |
| Uniprot ID: | COR1C_HUMAN |
| Immunogen Region: | 375-474 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 375-474 of human CORO1C (NP_055140.1). |
| Immunogen Sequence: | EEWFEGKNADPILISLKHGY IPGKNRDLKVVKKNILDSKP TANKKCDLISIPKKTTDTAS VQNEAKLDEILKEIKSIKDT ICNQDERISKLEQQMAKIAA |
| Tissue Specificity | Ubiquitous. |
| Function | Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells. Isoform 3: Involved in myogenic differentiation. |
| Protein Name | Coronin-1c Coronin-3 Hcrnn4 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasmic Side Cell Projection Lamellipodium Ruffle Membrane Cytoplasm Cytoskeleton Cell Cortex Endosome Membrane All Isoforms Colocalize With The Actin Cytoskeleton In The Cytosol And Especially In The Cell Cortex Colocalizes With F-Actin At The Leading Edge Of Lamellipodia Partially Colocalizes With Microtubules And Vimentin Intermediate Filaments Localizes To Endosome Membrane Tubules/Buds Isoform 3: Cell Membrane Sarcolemma Myofibril Sarcomere Synapse Colocalizes With The Thin Filaments Of The Sarcomere And With The Postsynaptic Area And The Junctional Sarcoplasm Of Motor End Plates Colocalizes With The Actin Cytoskeleton In The Cytosol |
| Alternative Antibody Names | Anti-Coronin-1c antibody Anti-Coronin-3 antibody Anti-Hcrnn4 antibody Anti-CORO1C antibody Anti-CRN2 antibody Anti-CRNN4 antibody |
Information sourced from Uniprot.org