| Function | Scavenger receptor that displays several functions associated with host defense. Promotes binding and phagocytosis of Gram-positive, Gram-negative bacteria and yeast. Mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. Binds to several carbohydrates including Gal-type ligands, D-galactose, L- and D-fucose, GalNAc, T and Tn antigens in a calcium-dependent manner and internalizes specifically GalNAc in nurse-like cells. Binds also to sialyl Lewis X or a trisaccharide and asialo-orosomucoid (ASOR). May also play a role in the clearance of amyloid-beta in Alzheimer disease. |
| Protein Name | Collectin-12Collectin Placenta Protein 1Cl-P1Hcl-P1Nurse Cell Scavenger Receptor 2Scavenger Receptor Class A Member 4Scavenger Receptor With C-Type Lectin |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-3000480 |
| Cellular Localisation | MembraneSingle-Pass Type Ii Membrane ProteinForms Clusters On The Cell Surface |
| Alternative Antibody Names | Anti-Collectin-12 antibodyAnti-Collectin Placenta Protein 1 antibodyAnti-Cl-P1 antibodyAnti-Hcl-P1 antibodyAnti-Nurse Cell Scavenger Receptor 2 antibodyAnti-Scavenger Receptor Class A Member 4 antibodyAnti-Scavenger Receptor With C-Type Lectin antibodyAnti-COLEC12 antibodyAnti-CLP1 antibodyAnti-NSR2 antibodyAnti-SCARA4 antibodyAnti-SRCL antibody |
Information sourced from Uniprot.org
