| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNOT2 |
| Gene ID: |
4848 |
| Uniprot ID: |
CNOT2_HUMAN |
| Immunogen Region: |
341-540 |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 341-540 of human CNOT2 (NP_055330.1). |
| Immunogen Sequence: |
GRVTNIPQGMVTDQFGMIGL LTFIRAAETDPGMVHLALGS DLTTLGLNLNSPENLYPKFA SPWASSPCRPQDIDFHVPSE YLTNIHIRDKLAAIKLGRYG EDLLFYLYYMNGGDVLQLLA AVELFNRDWRYHKEERVWIT RAPGMEPTMKTNTYERGTYY FFDCLNWRKVAKEFHLEYDK LEERPHLPSTFNYNPAQQAF |
| Tissue Specificity | Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes. |
| Function | Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation.the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity. |
| Protein Name | Ccr4-Not Transcription Complex Subunit 2Ccr4-Associated Factor 2 |
| Database Links | Reactome: R-HSA-429947Reactome: R-HSA-6804115Reactome: R-HSA-9820841 |
| Cellular Localisation | CytoplasmNucleus |
| Alternative Antibody Names | Anti-Ccr4-Not Transcription Complex Subunit 2 antibodyAnti-Ccr4-Associated Factor 2 antibodyAnti-CNOT2 antibodyAnti-CDC36 antibodyAnti-NOT2 antibodyAnti-HSPC131 antibodyAnti-MSTP046 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
