| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-cGMP-gated cation channel alpha-1 (401-450 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNGA1 |
| Gene ID: |
1259 |
| Uniprot ID: |
CNGA1_HUMAN |
| Immunogen Region: |
401-450 aa |
| Specificity: |
CNG-1 Polyclonal Antibody detects endogenous levels of CNG-1 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CNGA1 at the amino acid range 401-450 |
| Function | Pore-forming subunit of the rod cyclic nucleotide-gated channel. Mediates rod photoresponses at dim light converting transient changes in intracellular cGMP levels into electrical signals. In the dark, cGMP levels are high and keep the channel open enabling a steady inward current carried by Na(+) and Ca(2+) ions that leads to membrane depolarization and neurotransmitter release from synaptic terminals. Upon photon absorption cGMP levels decline leading to channel closure and membrane hyperpolarization that ultimately slows neurotransmitter release and signals the presence of light, the end point of the phototransduction cascade. Conducts cGMP- and cAMP-gated ion currents, with permeability for monovalent and divalent cations. The selectivity for Ca(2+) over Na(+) increases with cGMP concentrations, whereas the selectivity among monovalent ions is independent of the cGMP levels. |
| Protein Name | Cyclic Nucleotide-Gated Channel Alpha-1Cng Channel Alpha-1Cng-1Cng1Cyclic Nucleotide-Gated Channel - PhotoreceptorRod Photoreceptor Cgmp-Gated Cation Channel Subunit AlphaCgmp-Gated Cation Channel Alpha-1 |
| Database Links | Reactome: R-HSA-2485179Reactome: R-HSA-2514859 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Cyclic Nucleotide-Gated Channel Alpha-1 antibodyAnti-Cng Channel Alpha-1 antibodyAnti-Cng-1 antibodyAnti-Cng1 antibodyAnti-Cyclic Nucleotide-Gated Channel - Photoreceptor antibodyAnti-Rod Photoreceptor Cgmp-Gated Cation Channel Subunit Alpha antibodyAnti-Cgmp-Gated Cation Channel Alpha-1 antibodyAnti-CNGA1 antibodyAnti-CNCG antibodyAnti-CNCG1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
