| Tissue Specificity | Detected in placenta (at protein level). Widely expressed. High expression is found in placenta followed by lung and heart. Low expression in skeletal muscle, kidney and pancreas. |
| Function | In the soluble state, catalyzes glutaredoxin-like thiol disulfide exchange reactions with reduced glutathione as electron donor. Reduced in a glutathione-dependent way and secreted into the extracellular matrix where it activates TGM2 and promotes blood vessel growth during tissue remodeling as occurs in tumorigenesis. Can reduce specific cysteines in TGM2 and regulate cofactor binding. Can insert into membranes and form outwardly rectifying chloride ion channels. May participate in cellular growth control. |
| Protein Name | Chloride Intracellular Channel Protein 3Glutaredoxin-Like Oxidoreductase Clic3 |
| Cellular Localisation | NucleusMembraneSingle-Pass Membrane ProteinCell MembraneCytoplasmSecretedExtracellular SpaceExtracellular MatrixPredominantly NuclearSome Protein Was Found In The CytoplasmExists Both As Soluble Cytoplasmic Protein And As Membrane Protein With Probably A Single Transmembrane DomainSecreted Into The Extracellular Matrix By Activated Fibroblasts |
| Alternative Antibody Names | Anti-Chloride Intracellular Channel Protein 3 antibodyAnti-Glutaredoxin-Like Oxidoreductase Clic3 antibodyAnti-CLIC3 antibody |
Information sourced from Uniprot.org
