• Western blot analysis of MCF-7 lysate, antibody was diluted at 1000. Secondary antibody (STJ99666) was diluted at 1:20000

Anti-Cleaved-F2R-Ser42 antibody (STJ99660)

SKU:
STJ99660

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Cleaved-Proteinase-activated receptor 1-Ser42 is suitable for use in Western Blot and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
ELISA 1:10000-20000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: F2R
Gene ID: 2149
Uniprot ID: PAR1_HUMAN
Specificity: This antibody detects endogenous levels of PAR1 (Cleaved-Ser42).
Immunogen: Synthesized peptide derived from the human PAR1 (Cleaved-Ser42) Polyclonal
Post Translational Modifications Proteolytic cleavage by thrombin generates a new N-terminus that functions as a tethered ligand. Also proteolytically cleaved by cathepsin CTSG. Cleavage at 41-Arg-|-Ser-42 by CTSG results in receptor activation while cleavage at 55-Phe-|-Trp-56 results in inhibition of receptor activation. Phosphorylated in the C-terminal tail.probably mediating desensitization prior to the uncoupling and internalization of the receptor.
Function High affinity receptor for activated thrombin coupled to G proteins that stimulate phosphoinositide hydrolysis. May play a role in platelets activation and in vascular development.
Protein Name Proteinase-Activated Receptor 1
Par-1
Coagulation Factor Ii Receptor
Thrombin Receptor
Database Links Reactome: R-HSA-140875
Reactome: R-HSA-375276
Reactome: R-HSA-416476
Reactome: R-HSA-456926
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Proteinase-Activated Receptor 1 antibody
Anti-Par-1 antibody
Anti-Coagulation Factor Ii Receptor antibody
Anti-Thrombin Receptor antibody
Anti-F2R antibody
Anti-CF2R antibody
Anti-PAR1 antibody
Anti-TR antibody

Information sourced from Uniprot.org

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