| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:100-1:500ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLDN16 |
| Gene ID: |
10686 |
| Uniprot ID: |
CLD16_HUMAN |
| Immunogen Region: |
50-150 |
| Specificity: |
A synthetic peptide corresponding to a sequence within amino acids 50-150 of human CLDN16 (NP_006571.1). |
| Immunogen Sequence: |
HLSGARAGVCPCCHPDGLLA TMRDLLQYIACFFAFFSAGF LIVATWTDCWMVNADDSLEV STKCRGLWWECVTNAFDGIR TCDEYDSILAEHPLKLVVTR A |
| Tissue Specificity | Kidney-specific, including the thick ascending limb of Henle (TAL). |
| Function | Forms paracellular channels: coassembles with CLDN19 into tight junction strands with cation-selective channels through the strands, conveying epithelial permeability in a process known as paracellular tight junction permeability. Involved in the maintenance of ion gradients along the nephron. In the thick ascending limb (TAL) of Henle's loop, facilitates sodium paracellular permeability from the interstitial compartment to the lumen, contributing to the lumen-positive transepithelial potential that drives paracellular magnesium and calcium reabsorption. |
| Protein Name | Claudin-16Paracellin-1Pcln-1 |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinCotrafficks With Cldn19 From Er To Tight Junctions |
| Alternative Antibody Names | Anti-Claudin-16 antibodyAnti-Paracellin-1 antibodyAnti-Pcln-1 antibodyAnti-CLDN16 antibodyAnti-PCLN1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
