| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Claudin-1 (111-211) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:1000-1:5000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CLDN1 |
| Gene ID: |
9076 |
| Uniprot ID: |
CLD1_HUMAN |
| Immunogen Region: |
111-211 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 111-211 of human Claudin 1 (NP_066924.1). |
| Immunogen Sequence: |
DEVQKMRMAVIGGAIFLLAG LAILVATAWYGNRIVQEFYD PMTPVNARYEFGQALFTGWA AASLCLLGGALLCCSCPRKT TSYPTPRPYPKPAPSSGKDY V |
| Tissue Specificity | Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis. |
| Function | Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. (Microbial infection) Acts as a co-receptor for hepatitis C virus (HCV) in hepatocytes. Associates with CD81 and the CLDN1-CD81 receptor complex is essential for HCV entry into host cell. Acts as a receptor for dengue virus. |
| Protein Name | Claudin-1Senescence-Associated Epithelial Membrane Protein |
| Database Links | Reactome: R-HSA-420029 |
| Cellular Localisation | Cell JunctionTight JunctionCell MembraneMulti-Pass Membrane ProteinBasolateral Cell MembraneAssociates With Cd81 And The Cldn1-Cd81 Complex Localizes To The Basolateral Cell Membrane |
| Alternative Antibody Names | Anti-Claudin-1 antibodyAnti-Senescence-Associated Epithelial Membrane Protein antibodyAnti-CLDN1 antibodyAnti-CLD1 antibodyAnti-SEMP1 antibodyAnti-UNQ481 antibodyAnti-PRO944 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
