| Tissue Specificity | Widely expressed. Highly expressed in bone marrow, peripheral blood leukocytes, spleen, brain, spinal cord, ovary and placenta. Expressed by high endothelial cells (HEVs) and leukocytes. |
| Post Translational Modifications | Glycosylation at Asn-475 is required for catalytic activity. |
| Function | Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues within keratan-like structures on N-linked glycans and within mucin-associated glycans that can ultimately serve as SELL ligands. SELL ligands are present in high endothelial cells (HEVs) and play a central role in lymphocyte homing at sites of inflammation. Participates in biosynthesis of the SELL ligand sialyl 6-sulfo Lewis X and in lymphocyte homing to Peyer patches. Has no activity toward O-linked sugars. Its substrate specificity may be influenced by its subcellular location. Sulfates GlcNAc residues at terminal, non-reducing ends of oligosaccharide chains. |
| Protein Name | Carbohydrate Sulfotransferase 2Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 2Gst-2N-Acetylglucosamine 6-O-Sulfotransferase 1Glcnac6st-1Gn6st-1 |
| Database Links | Reactome: R-HSA-2022854 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi Network MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Carbohydrate Sulfotransferase 2 antibodyAnti-Galactose/N-Acetylglucosamine/N-Acetylglucosamine 6-O-Sulfotransferase 2 antibodyAnti-Gst-2 antibodyAnti-N-Acetylglucosamine 6-O-Sulfotransferase 1 antibodyAnti-Glcnac6st-1 antibodyAnti-Gn6st-1 antibodyAnti-CHST2 antibodyAnti-GN6ST antibody |
Information sourced from Uniprot.org
