| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CHN2 (1-200) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CHN2 |
| Gene ID: |
1124 |
| Uniprot ID: |
CHIO_HUMAN |
| Immunogen Region: |
1-200 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human CHN2 (NP_004058.1). |
| Immunogen Sequence: |
MAASSNSSLSGSSVSSDAEE YQPPIWKSYLYQLQQEAPRP KRIICPREVENRPKYYGREF HGIISREQADELLGGVEGAY ILRESQRQPGCYTLALRFGN QTLNYRLFHDGKHFVGEKRF ESIHDLVTDGLITLYIETKA AEYISKMTTNPIYEHIGYAT LLREKVSRRLSRSKNEPRKT NVTHEEHTAVEKISSLVRRA |
| Tissue Specificity | Highest levels in the brain and pancreas. Also expressed in the heart, placenta, and weakly in the kidney and liver. Expression is much reduced in the malignant gliomas, compared to normal brain or low-grade astrocytomas. |
| Function | GTPase-activating protein for p21-rac. Insufficient expression of beta-2 chimaerin is expected to lead to higher Rac activity and could therefore play a role in the progression from low-grade to high-grade tumors. |
| Protein Name | Beta-ChimaerinBeta-ChimerinRho Gtpase-Activating Protein 3 |
| Database Links | Reactome: R-HSA-9013149 |
| Cellular Localisation | MembranePeripheral Membrane Protein |
| Alternative Antibody Names | Anti-Beta-Chimaerin antibodyAnti-Beta-Chimerin antibodyAnti-Rho Gtpase-Activating Protein 3 antibodyAnti-CHN2 antibodyAnti-ARHGAP3 antibodyAnti-BCH antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
