• Western blot analysis of lysates from HeLa and HUVEC cells, using CMKLR1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of 293T lysis using ChemR23 antibody. Antibody was diluted at 1:1000
  • Western blot analysis of COLO205 cells using ChemR23 Polyclonal Antibody diluted at 1：1000
  • Western blot analysis of 293T lysis using ChemR23 antibody. Antibody was diluted at 1:1000
  • Western blot analysis of various cells using ChemR23 Polyclonal Antibody diluted at 1：1000

Anti-CMKLR1 antibody (221-270 aa) (STJ92262)

SKU:
STJ92262

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Chemerin-like receptor 1 (221-270 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
IF 1:100-300
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CMKLR1
Gene ID: 1240
Uniprot ID: CML1_HUMAN
Immunogen Region: 221-270 aa
Specificity: ChemR23 Polyclonal Antibody detects endogenous levels of ChemR23 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CMKLR1 at the amino acid range 221-270
Function Receptor for the chemoattractant adipokine chemerin/RARRES2 and for the omega-3 fatty acid derived molecule resolvin E1. Interaction with RARRES2 initiates activation of G proteins G(i)/G(o) and beta-arrestin pathways inducing cellular responses via second messenger pathways such as intracellular calcium mobilization, phosphorylation of MAP kinases MAPK1/MAPK3 (ERK1/2), TYRO3, MAPK14/P38MAPK and PI3K leading to multifunctional effects, like reduction of immune responses, enhancing of adipogenesis and angionesis. Resolvin E1 down-regulates cytokine production in macrophages by reducing the activation of MAPK1/3 (ERK1/2) and NF-kappa-B. Positively regulates adipogenesis and adipocyte metabolism. (Microbial infection) Acts as a coreceptor for several SIV strains (SIVMAC316, SIVMAC239, SIVMACL7E-FR and SIVSM62A), as well as a primary HIV-1 strain (92UG024-2).
Protein Name Chemerin-Like Receptor 1
Chemokine-Like Receptor 1
G-Protein Coupled Receptor Chemr23
G-Protein Coupled Receptor Dez
Database Links Reactome: R-HSA-373076
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Internalizes Efficiently In Response To Rarres2
Alternative Antibody Names Anti-Chemerin-Like Receptor 1 antibody
Anti-Chemokine-Like Receptor 1 antibody
Anti-G-Protein Coupled Receptor Chemr23 antibody
Anti-G-Protein Coupled Receptor Dez antibody
Anti-CMKLR1 antibody
Anti-CHEMR23 antibody
Anti-DEZ antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance