• Immunohistochemistry analysis of paraffin-embedded mouse brain using CHD4 Rabbit monoclonal antibody (STJ11105141) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human spleen using CHD4 Rabbit monoclonal antibody (STJ11105141) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of paraffin-embedded human liver using CHD4 Rabbit monoclonal antibody (STJ11105141) at dilution of 1:200 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.

Anti-CHD4 antibody [S5141RM] (STJ11105141)

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STJ11105141

£146.50 - £639.50
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Host: Rabbit
Applications: IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit monoclonal antibody anti-Chromodomain-Helicase-Dna-Binding Protein 4 is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: S5141RM
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: IHC-P 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CHD4
Gene ID: 1108
Uniprot ID: CHD4_HUMAN
Immunogen: Recombinant protein of human CHD4.
Tissue Specificity Widely expressed.
Function ATP-dependent helicase that binds and distorts nucleosomal DNA. Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin. Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination. Involved in neurogenesis.
Protein Name Chromodomain-Helicase-Dna-Binding Protein 4
Chd-4
Atp-Dependent Helicase Chd4
Mi-2 Autoantigen 218 Kda Protein
Mi2-Beta
Database Links Reactome: R-HSA-3214815
Reactome: R-HSA-427389
Reactome: R-HSA-6804758
Reactome: R-HSA-73762
Reactome: R-HSA-8943724
Reactome: R-HSA-9031628
Reactome: R-HSA-9679191
Cellular Localisation Nucleus
Cytoplasm
Cytoskeleton
Microtubule Organizing Center
Centrosome
Associates With Centrosomes In Interphase
Localizes To Sites Of Dna Damage In A Manner Dependent On Zmynd8 And Znf687
Alternative Antibody Names Anti-Chromodomain-Helicase-Dna-Binding Protein 4 antibody
Anti-Chd-4 antibody
Anti-Atp-Dependent Helicase Chd4 antibody
Anti-Mi-2 Autoantigen 218 Kda Protein antibody
Anti-Mi2-Beta antibody
Anti-CHD4 antibody

Information sourced from Uniprot.org

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