| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CERKL (359-558) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CERKL |
| Gene ID: |
375298 |
| Uniprot ID: |
CERKL_HUMAN |
| Immunogen Region: |
359-558 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 359-558 of human CERKL (NP_001025482.1). |
| Immunogen Sequence: |
LAEKYRWMSPNQRRDFAVVK ALAKLKAEDCEISFLPFNSS DDVQERRAQGSPKSDCNDQW QMIQGQFLNVSIMAIPCLCS VAPRGLAPNTRLNNGSMALI IARNTSRPEFIKHLKRYASV KNQFNFPFVETYTVEEVKVH PRNNTGGYNPEEEEDETASE NCFPWNVDGDLMEVASEVHI RLHPRLISLYGGSMEEMIPK |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in adult retina, liver and pancreas as well as in fetal brain, lung and kidney. Isoform 3 is expressed in adult retina as well as in fetal lung and liver. Isoform 4 is expressed in adult retina, lung and kidney as well as in fetal lung and liver. Moderately expressed in retina, kidney, lung, testis, trachea, and pancreas. Weakly expressed in brain, placenta and liver. |
| Post Translational Modifications | Phosphorylated on serine residues. |
| Function | Has no detectable ceramide-kinase activity. Overexpression of CERKL protects cells from apoptosis in oxidative stress conditions. |
| Protein Name | Ceramide Kinase-Like Protein |
| Cellular Localisation | CytoplasmNucleusNucleolusEnriched In NucleoliMay Shuttle Between Nucleus And CytoplasmIsoform 5 Is Not Enriched In The NucleoliIsoform 2: CytoplasmGolgi ApparatusTrans-Golgi NetworkEndoplasmic Reticulum |
| Alternative Antibody Names | Anti-Ceramide Kinase-Like Protein antibodyAnti-CERKL antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
