| Function | Acts as a regulator of centriole duplication through a direct interaction with STIL, a key factor involved in the early steps of centriole formation. The CEP85-STIL protein complex acts as a modulator of PLK4-driven cytoskeletal rearrangements and directional cell motility. Acts as a negative regulator of NEK2 to maintain the centrosome integrity in interphase. Suppresses centrosome disjunction by inhibiting NEK2 kinase activity. |
| Protein Name | Centrosomal Protein Of 85 KdaCep85Coiled-Coil Domain-Containing Protein 21 |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleNucleusNucleolusCentrioleCell CortexLocalizes To Centrosomes And Nucleolus In InterphaseUpon Entry Into MitosisRelocates From Nucleolus And Accumulates At Spindle PolesAssociated With The Pericentriolar MaterialLocalizes To Centrosomes At A Low Level In G1 Phase And A Slightly Increased Level In S PhaseWith Gradually Elevated Levels During G2 PhaseThe Levels At Centrosomes Further Increase At G2/MReaching A Peak At Spindle Poles At Early Mitotic Stages And Remain High Until The End Of AnaphaseLocalizes At The Leading Edge |
| Alternative Antibody Names | Anti-Centrosomal Protein Of 85 Kda antibodyAnti-Cep85 antibodyAnti-Coiled-Coil Domain-Containing Protein 21 antibodyAnti-CEP85 antibodyAnti-CCDC21 antibody |
Information sourced from Uniprot.org
