| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000IF/ICC:1:10-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDKAL1 |
| Gene ID: | 54901 |
| Uniprot ID: | CDKAL_HUMAN |
| Immunogen Region: | 1-230 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-230 of human CDKAL1 (NP_060244.2). |
| Immunogen Sequence: | MPSASCDTLLDDIEDIVSQE DSKPQDRHFVRKDVVPKVRR RNTQKYLQEEENSPPSDSTI PGIQKIWIRTWGCSHNNSDG EYMAGQLAAYGYKITENASD ADLWLLNSCTVKNPAEDHFR NSIKKAQEENKKIVLAGCVP QAQPRQDYLKGLSIIGVQQI DRVVEVVEETIKGHSVRLLG QKKDNGRRLGGARLDLPKIR KNPLIEIISINTGCLNACTY CKTKHARGNL |
| Tissue Specificity | Expressed in pancreatic islets. |
| Function | Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. |
| Protein Name | Threonylcarbamoyladenosine Trna MethylthiotransferaseCdk5 Regulatory Subunit-Associated Protein 1-Like 1Trna-T(6a37 Methylthiotransferase |
| Database Links | Reactome: R-HSA-6782315 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinIs A Tail-Anchored Protein That Exploits The Tcr40 Pathway For Insertion Into The Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Threonylcarbamoyladenosine Trna Methylthiotransferase antibodyAnti-Cdk5 Regulatory Subunit-Associated Protein 1-Like 1 antibodyAnti-Trna-T(6a37 Methylthiotransferase antibodyAnti-CDKAL1 antibody |
Information sourced from Uniprot.org