• Western blot analysis of lysates from human brain, using CDK14 Rabbit polyclonal antibody (STJ24966). Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST.

Anti-CDK14 antibody (312-451) (STJ24966)

SKU:
STJ24966

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Host: Rabbit
Applications: WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-CDK14 (312-451) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: CDK14
Gene ID: 5218
Uniprot ID: CDK14_HUMAN
Immunogen Region: 312-451
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 312-451 of human CDK14 (NP_036527.1).
Immunogen Sequence: AAFPGMKDIQDQLERIFLVL GTPNEDTWPGVHSLPHFKPE RFTLYSSKNLRQAWNKLSYV NHAEDLASKLLQCSPKNRLS AQAALSHEYFSDLPPRLWEL TDMSSIFTVPNVRLQPEAGE SMRAFGKNNSYGKSLSNSKH
Tissue Specificity Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected.
Function Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport.
Protein Name Cyclin-Dependent Kinase 14
Cell Division Protein Kinase 14
Serine/Threonine-Protein Kinase Pftaire-1
Hpftaire1
Cellular Localisation Cell Membrane
Peripheral Membrane Protein
Cytoplasm
Nucleus
Recruited To The Cell Membrane By Ccny
Alternative Antibody Names Anti-Cyclin-Dependent Kinase 14 antibody
Anti-Cell Division Protein Kinase 14 antibody
Anti-Serine/Threonine-Protein Kinase Pftaire-1 antibody
Anti-Hpftaire1 antibody
Anti-CDK14 antibody
Anti-KIAA0834 antibody
Anti-PFTK1 antibody

Information sourced from Uniprot.org

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