| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDK14 |
| Gene ID: | 5218 |
| Uniprot ID: | CDK14_HUMAN |
| Immunogen Region: | 312-451 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 312-451 of human CDK14 (NP_036527.1). |
| Immunogen Sequence: | AAFPGMKDIQDQLERIFLVL GTPNEDTWPGVHSLPHFKPE RFTLYSSKNLRQAWNKLSYV NHAEDLASKLLQCSPKNRLS AQAALSHEYFSDLPPRLWEL TDMSSIFTVPNVRLQPEAGE SMRAFGKNNSYGKSLSNSKH |
| Tissue Specificity | Highly expressed in brain, pancreas, kidney, heart, testis and ovary. Also detected at lower levels in other tissues except in spleen and thymus where expression is barely detected. |
| Function | Serine/threonine-protein kinase involved in the control of the eukaryotic cell cycle, whose activity is controlled by an associated cyclin. Acts as a cell-cycle regulator of Wnt signaling pathway during G2/M phase by mediating the phosphorylation of LRP6 at 'Ser-1490', leading to the activation of the Wnt signaling pathway. Acts as a regulator of cell cycle progression and cell proliferation via its interaction with CCDN3. Phosphorylates RB1 in vitro, however the relevance of such result remains to be confirmed in vivo. May also play a role in meiosis, neuron differentiation and may indirectly act as a negative regulator of insulin-responsive glucose transport. |
| Protein Name | Cyclin-Dependent Kinase 14 Cell Division Protein Kinase 14 Serine/Threonine-Protein Kinase Pftaire-1 Hpftaire1 |
| Cellular Localisation | Cell Membrane Peripheral Membrane Protein Cytoplasm Nucleus Recruited To The Cell Membrane By Ccny |
| Alternative Antibody Names | Anti-Cyclin-Dependent Kinase 14 antibody Anti-Cell Division Protein Kinase 14 antibody Anti-Serine/Threonine-Protein Kinase Pftaire-1 antibody Anti-Hpftaire1 antibody Anti-CDK14 antibody Anti-KIAA0834 antibody Anti-PFTK1 antibody |
Information sourced from Uniprot.org