| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CDCA2 |
| Gene ID: | 157313 |
| Uniprot ID: | CDCA2_HUMAN |
| Immunogen Region: | 724-1023 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 724-1023 of human CDCA2 (NP_689775.2). |
| Immunogen Sequence: | SDSPKPALTLQQGQEFSAGG QNAENLCQFFKISPDLNIKC ERKDDFLGAAEGKLQCNRLM PNSQKDCHCLGDVLIENTKE SKSQSEDLGRKPMESSSVVS CRDRKDRRRSMCYSDGRSLH LEKNGNHTPSSSVGSSVEIS LENSELFKDLSDAIEQTFQR RNSETKVRRSTRLQKDLENE GLVWISLPLPSTSQKAKRRT ICTFDSSGFESMSPIKETVS SRQKPQMAPPVSDPENSQG |
| Tissue Specificity | Ubiquitously expressed. |
| Post Translational Modifications | Phosphorylated by CDK1. May regulate its subcellular location. |
| Function | Regulator of chromosome structure during mitosis required for condensin-depleted chromosomes to retain their compact architecture through anaphase. Acts by mediating the recruitment of phopsphatase PP1-gamma subunit (PPP1CC) to chromatin at anaphase and into the following interphase. At anaphase onset, its association with chromatin targets a pool of PPP1CC to dephosphorylate substrates. |
| Protein Name | Cell Division Cycle-Associated Protein 2 Recruits Pp1 Onto Mitotic Chromatin At Anaphase Protein Repo-Man |
| Cellular Localisation | Nucleus Excluded From The Nucleolus Present In Nucleoplasm Throughout The G1 S And G2 Stages Of The Cell Cycle During M Phase It Becomes Diffuse Throughout The Cell As The Nuclear Membrane Breaks Down And Faintly Accumulates Later On Metaphase Chromatin As The Cell Progresses To Anaphase It Accumulates On Chromatin |
| Alternative Antibody Names | Anti-Cell Division Cycle-Associated Protein 2 antibody Anti-Recruits Pp1 Onto Mitotic Chromatin At Anaphase Protein antibody Anti-Repo-Man antibody Anti-CDCA2 antibody |
Information sourced from Uniprot.org