| Function | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing. |
| Protein Name | Dual Specificity Protein Phosphatase Cdc14aCdc14 Cell Division Cycle 14 Homolog A |
| Database Links | Reactome: R-HSA-176407Reactome: R-HSA-5687128 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindleCell ProjectionKinociliumStereociliumCentrosomal During InterphaseReleased Into The Cytoplasm At The Onset Of MitosisSubsequently Localizes To The Mitotic Spindle Pole And At The Central SpindlePresent Along Both The Transient Kinocilia Of Developing Cochlear Hair Cells And The Persistent Kinocilia Of Vestibular Hair Cells |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase Cdc14a antibodyAnti-Cdc14 Cell Division Cycle 14 Homolog A antibodyAnti-CDC14A antibody |
Information sourced from Uniprot.org
