| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
CDC14A |
| Gene ID: |
8556 |
| Uniprot ID: |
CC14A_HUMAN |
| Immunogen Region: |
180-260 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 180-260 of human CDC14A (NP_201569.1). |
| Immunogen Sequence: |
FNWIVPGKFLAFSGPHPKSK IENGYPLHAPEAYFPYFKKH NVTAVVRLNKKIYEAKRFTD AGFEHYDLFFIDGSTPSDNI V |
| Function | Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing. |
| Protein Name | Dual Specificity Protein Phosphatase Cdc14aCdc14 Cell Division Cycle 14 Homolog A |
| Database Links | Reactome: R-HSA-176407Reactome: R-HSA-5687128 |
| Cellular Localisation | NucleusCytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeSpindle PoleSpindleCell ProjectionKinociliumStereociliumCentrosomal During InterphaseReleased Into The Cytoplasm At The Onset Of MitosisSubsequently Localizes To The Mitotic Spindle Pole And At The Central SpindlePresent Along Both The Transient Kinocilia Of Developing Cochlear Hair Cells And The Persistent Kinocilia Of Vestibular Hair Cells |
| Alternative Antibody Names | Anti-Dual Specificity Protein Phosphatase Cdc14a antibodyAnti-Cdc14 Cell Division Cycle 14 Homolog A antibodyAnti-CDC14A antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
