| Host: | Mouse |
| Applications: | IHC-P |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-CD71 is suitable for use in Immunohistochemistry research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 10F11 |
| Conjugation: | Unconjugated |
| Isotype: | IgG2b |
| Formulation: | Tissue culture supernatant with sodium azide |
| Concentration: | >=42 mg/L |
| Dilution Range: | IHC-P 1:80 |
| Storage Instruction: | Store at 2-8°C upon receipt. |
| Immunogen: | Prokaryotic recombinant protein corresponding to a region of the N-terminal intracellular domain of the human CD71 molecule. |
| Background | The CD71 molecule is a type II membrane glycoprotein with a molecular weight of approximately 180 kD. It is known as the transferrin receptor and is composed of two disulfide-bonded 90 kD subunits. The CD71 molecule plays a critical role in cell proliferation by controlling the supply of iron, an essential component for many metabolic pathways, through the binding and endocytosis of transferrin, the major iron-carrying protein. CD71 protein is reported to be expressed on activated B and T cells, macrophages, proliferating cells and metabolically active cells, for example, neurons. |
Information sourced from Uniprot.org