| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD48 |
| Gene ID: | 962 |
| Uniprot ID: | CD48_HUMAN |
| Immunogen Region: | 45-210 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 45-210 of human CD48 (NP_001769.2). |
| Immunogen Sequence: | ISESLPENYKQLTWFYTFDQ KIVEWDSRKSKYFESKFKGR VRLDPQSGALYISKVQKEDN STYIMRVLKKTGNEQEWKIK LQVLDPVPKPVIKIEKIEDM DDNCYLKLSCVIPGESVNYT WYGDKRPFPKELQNSVLETT LMPHNYSRCYTCQVSNSVSS KNGTVC |
| Tissue Specificity | Widely expressed on all hematopoietic cells. |
| Function | Glycosylphosphatidylinositol (GPI)-anchored cell surface glycoprotein that interacts via its N-terminal immunoglobulin domain with cell surface receptors including CD244/2B4 or CD2 to regulate immune cell function and activation. Participates in T-cell signaling transduction by associating with CD2 and efficiently bringing the Src family protein kinase LCK and LAT to the TCR/CD3 complex. In turn, promotes LCK phosphorylation and subsequent activation. Induces the phosphorylation of the cytoplasmic immunoreceptortyrosine switch motifs (ITSMs) of CD244 initiating a series of signaling events that leads to the generation of the immunological synapse and the directed release of cytolytic granules containing perforin and granzymes by T-lymphocytes and NK-cells. |
| Protein Name | Cd48 Antigen B-Lymphocyte Activation Marker Blast-1 Bcm1 Surface Antigen Leukocyte Antigen Mem-102 Slam Family Member 2 Slamf2 Signaling Lymphocytic Activation Molecule 2 Tct.1 Cd Antigen Cd48 |
| Database Links | Reactome: R-HSA-202733 |
| Cellular Localisation | Cell Membrane Lipid-Anchor Gpi-Anchor Membrane Raft Secreted |
| Alternative Antibody Names | Anti-Cd48 Antigen antibody Anti-B-Lymphocyte Activation Marker Blast-1 antibody Anti-Bcm1 Surface Antigen antibody Anti-Leukocyte Antigen Mem-102 antibody Anti-Slam Family Member 2 antibody Anti-Slamf2 antibody Anti-Signaling Lymphocytic Activation Molecule 2 antibody Anti-Tct.1 antibody Anti-Cd Antigen Cd48 antibody Anti-CD48 antibody Anti-BCM1 antibody Anti-BLAST1 antibody |
Information sourced from Uniprot.org