| Host: |
Rabbit |
| Applications: |
WB/FC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-CD28 is suitable for use in Western Blot and Flow Cytometry research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S5MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000FC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CD28 |
| Gene ID: |
940 |
| Uniprot ID: |
CD28_HUMAN |
| Immunogen: |
Recombinant protein of human CD28 Full length ( P10747 ). |
| Immunogen Sequence: |
MLRLLLALNLFPSIQVTGNK ILVKQSPMLVAYDNAVNLSC KYSYNLFSREFRASLHKGLD SAVEVCVVYGNYSQQLQVYS KTGFNCDGKLGNESVTFYLQ NLYVNQTDIYFCKIEVMYPP PYLDNEKSNGTIIHVKGKHL CPSPLFPGPSKPFWVLVVVG GVLACYSLLVTVAFIIFWVR SKRSRLLHSDYMNMTPRRPG PTRKHYQPYAPPRDFAAYRS |
| Tissue Specificity | Expressed in T-cells and plasma cells, but not in less mature B-cells. |
| Post Translational Modifications | CD40LG induces tyrosine phosphorylation of isoform 3. |
| Function | Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells. |
| Protein Name | T-Cell-Specific Surface Glycoprotein Cd28Tp44Cd Antigen Cd28 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-164939Reactome: R-HSA-2219530Reactome: R-HSA-389356Reactome: R-HSA-389357Reactome: R-HSA-389359Reactome: R-HSA-6811558 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinIsoform 3: Cell Surface |
| Alternative Antibody Names | Anti-T-Cell-Specific Surface Glycoprotein Cd28 antibodyAnti-Tp44 antibodyAnti-Cd Antigen Cd28 antibodyAnti-CD28 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
