| Host: | Rabbit |
| Applications: | IHC-P/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IHC-P:1:50 0-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | CD207 |
| Gene ID: | 50489 |
| Uniprot ID: | CLC4K_HUMAN |
| Immunogen Region: | 65-328 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 65-328 of human Langerin/CD207 (NP_056532.4). |
| Immunogen Sequence: | PRFMGTISDVKTNVQLLKGR VDNISTLDSEIKKNSDGMEA AGVQIQMVNESLGYVRSQFL KLKTSVEKANAQIQILTRSW EEVSTLNAQIPELKSDLEKA SALNTKIRALQGSLENMSKL LKRQNDILQVVSQGWKYFKG NFYYFSLIPKTWYSAEQFCV SRNSHLTSVTSESEQEFLYK TAGGLIYWIGLTKAGMEGDW SWVDDTPFNKVQSVRFWIPG EPNNAGNNEHCGNIKAPSL |
| Tissue Specificity | Exclusively expressed by Langerhans cells. Expressed in astrocytoma and malignant ependymoma, but not in normal brain tissues. |
| Function | Calcium-dependent lectin displaying mannose-binding specificity. Induces the formation of Birbeck granules (BGs).is a potent regulator of membrane superimposition and zippering. Binds to sulfated as well as mannosylated glycans, keratan sulfate (KS) and beta-glucans. Facilitates uptake of antigens and is involved in the routing and/or processing of antigen for presentation to T cells. Major receptor on primary Langerhans cells for Candida species, Saccharomyces species, and Malassezia furfur. Protects against human immunodeficiency virus-1 (HIV-1) infection. Binds to high-mannose structures present on the envelope glycoprotein which is followed by subsequent targeting of the virus to the Birbeck granules leading to its rapid degradation. |
| Protein Name | C-Type Lectin Domain Family 4 Member K Langerin Cd Antigen Cd207 |
| Database Links | Reactome: R-HSA-1236978 |
| Cellular Localisation | Membrane Single-Pass Type Ii Membrane Protein Found In Birbeck Granules (Bgs) Which Are Organelles Consisting Of Superimposed And Zippered Membranes |
| Alternative Antibody Names | Anti-C-Type Lectin Domain Family 4 Member K antibody Anti-Langerin antibody Anti-Cd Antigen Cd207 antibody Anti-CD207 antibody Anti-CLEC4K antibody |
Information sourced from Uniprot.org