| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | Cdh5 |
| Gene ID: | 12562 |
| Uniprot ID: | CADH5_MOUSE |
| Immunogen Region: | 46-592 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 46-592 of mouse CD144 (NP_033998.2). |
| Immunogen Sequence: | DWIWNQMHIDEEKNESLPHY VGKIKSNVNRQNAKYVLQGE FAGKIFGVDANTGNVLAYER LDREKVSEYFLTALIVDKNT NKNLEQPSSFTVKVHDINDN WPVFSHQVFNASVPEMSAIG TSVIRVTAVDADDPTVAGHA TVLYQIVKGNEYFSIDNSGL IFTKIKNLDREKQAEYKIVV ETQDALGLRGESGTATVMIR LEDINDNFPVFTQSTYTFSV PEDIRVGKPLGFLTVVDPD |
| Tissue Specificity | Expressed in postnatal endothelial cells of the retinal vascular plexus (at protein level). |
| Post Translational Modifications | Phosphorylated on tyrosine residues by KDR/VEGFR-2. Dephosphorylated by PTPRB. O-glycosylated. |
| Function | Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells.cadherins may thus contribute to the sorting of heterogeneous cell types. This cadherin may play an important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions. It associates with alpha-catenin forming a link to the cytoskeleton. Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1. Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen. These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B. Required for activation of PRKCZ and for localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction. |
| Protein Name | Cadherin-5 Vascular Endothelial Cadherin Ve-Cadherin Cd Antigen Cd144 |
| Database Links | Reactome: R-MMU-418990 Reactome: -MMU-5218920 |
| Cellular Localisation | Cell Junction Adherens Junction Cell Membrane Single-Pass Type I Membrane Protein Cytoplasm Found At Cell-Cell Boundaries And Probably At Cell-Matrix Boundaries Krit1 And Cdh5 Reciprocally Regulate Their Localization To Endothelial Cell-Cell Junctions |
| Alternative Antibody Names | Anti-Cadherin-5 antibody Anti-Vascular Endothelial Cadherin antibody Anti-Ve-Cadherin antibody Anti-Cd Antigen Cd144 antibody Anti-Cdh5 antibody |
Information sourced from Uniprot.org