| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD107b is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
Lamp2 |
| Gene ID: |
16784 |
| Uniprot ID: |
LAMP2_MOUSE |
| Immunogen: |
Recombinant protein of mouse CD107b. |
| Tissue Specificity | Detected in liver and kidney (at protein level). Detected in liver and kidney. |
| Post Translational Modifications | Extensively N-glycosylated. Contains a minor proportion of O-linked glycans. |
| Function | Lysosomal membrane glycoprotein which plays an important role in lysosome biogenesis, lysosomal pH regulation and autophagy. Acts as an important regulator of lysosomal lumen pH regulation by acting as a direct inhibitor of the proton channel TMEM175, facilitating lysosomal acidification for optimal hydrolase activity. Plays an important role in chaperone-mediated autophagy, a process that mediates lysosomal degradation of proteins in response to various stresses and as part of the normal turnover of proteins with a long biological half-live. Functions by binding target proteins, such as GAPDH, NLRP3 and MLLT11, and targeting them for lysosomal degradation. In the chaperone-mediated autophagy, acts downstream of chaperones, such as HSPA8/HSC70, which recognize and bind substrate proteins and mediate their recruitment to lysosomes, where target proteins bind LAMP2. Plays a role in lysosomal protein degradation in response to starvation. Required for the fusion of autophagosomes with lysosomes during autophagy. Cells that lack LAMP2 express normal levels of VAMP8, but fail to accumulate STX17 on autophagosomes, which is the most likely explanation for the lack of fusion between autophagosomes and lysosomes. Required for normal degradation of the contents of autophagosomes. Required for efficient MHCII-mediated presentation of exogenous antigens via its function in lysosomal protein degradation.antigenic peptides generated by proteases in the endosomal/lysosomal compartment are captured by nascent MHCII subunits. Is not required for efficient MHCII-mediated presentation of endogenous antigens. |
| Protein Name | Lysosome-Associated Membrane Glycoprotein 2Lamp-2Lysosome-Associated Membrane Protein 2Cd107 Antigen-Like Family Member BLysosomal Membrane Glycoprotein Type BLgp-BCd Antigen Cd107b |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-6798695 |
| Cellular Localisation | Lysosome MembraneSingle-Pass Type I Membrane ProteinEndosome MembraneCytoplasmic VesicleAutophagosome MembraneCell MembraneThis Protein Shuttles Between LysosomesEndosomesAnd The Plasma Membrane |
| Alternative Antibody Names | Anti-Lysosome-Associated Membrane Glycoprotein 2 antibodyAnti-Lamp-2 antibodyAnti-Lysosome-Associated Membrane Protein 2 antibodyAnti-Cd107 Antigen-Like Family Member B antibodyAnti-Lysosomal Membrane Glycoprotein Type B antibodyAnti-Lgp-B antibodyAnti-Cd Antigen Cd107b antibodyAnti-Lamp2 antibodyAnti-Lamp-2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
