| Host: |
Rabbit |
| Applications: |
IF/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-C-C chemokine receptor type 4 (211-260 aa) is suitable for use in Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCR4 |
| Gene ID: |
1233 |
| Uniprot ID: |
CCR4_HUMAN |
| Immunogen Region: |
211-260 aa |
| Specificity: |
CKR-4 Polyclonal Antibody detects endogenous levels of CKR-4 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human CCR4 at the amino acid range 211-260 |
| Post Translational Modifications | In natural killer cells, CCL22 binding induces phosphorylation on yet undefined Ser/Thr residues, most probably by beta-adrenergic receptor kinases 1 and 2. |
| Function | High affinity receptor for the C-C type chemokines CCL17/TARC, CCL22/MDC and CKLF isoform 1/CKLF1. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Can function as a chemoattractant homing receptor on circulating memory lymphocytes and as a coreceptor for some primary HIV-2 isolates. In the CNS, could mediate hippocampal-neuron survival. |
| Protein Name | C-C Chemokine Receptor Type 4C-C Ckr-4Cc-Ckr-4Ccr-4Ccr4K5-5Cd Antigen Cd194 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-C-C Chemokine Receptor Type 4 antibodyAnti-C-C Ckr-4 antibodyAnti-Cc-Ckr-4 antibodyAnti-Ccr-4 antibodyAnti-Ccr4 antibodyAnti-K5-5 antibodyAnti-Cd Antigen Cd194 antibodyAnti-CCR4 antibodyAnti-CMKBR4 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
