| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CCL20 (1-95) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CCL20 |
| Gene ID: |
6364 |
| Uniprot ID: |
CCL20_HUMAN |
| Immunogen Region: |
1-95 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 1-95 of human CCL20 (NP_004582.1). |
| Immunogen Sequence: |
MCCTKSLLLAALMSVLLLHL CGESEAASNFDCCLGYTDRI LHPKFIVGFTRQLANEGCDI NAIIFHTKKKLSVCANPKQT WVKYIVRLLSKKVKN |
| Tissue Specificity | Expressed in the seminal plasma, endometrial fluid and follicular fluid (at protein level). Expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, and fetal lung. Low levels seen in thymus, prostate, testis, small intestine and colon. |
| Post Translational Modifications | C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes. |
| Function | Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the pro-inflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. C-terminal processed forms have been shown to be equally chemotactically active for leukocytes. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. Inhibits proliferation of myeloid progenitors in colony formation assays. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells. Possesses antibacterial activity towards E.coli ATCC 25922 and S.aureus ATCC 29213. |
| Protein Name | C-C Motif Chemokine 20Beta-Chemokine Exodus-1Cc Chemokine LarcLiver And Activation-Regulated ChemokineMacrophage Inflammatory Protein 3 AlphaMip-3-AlphaSmall-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70 |
| Database Links | Reactome: R-HSA-380108Reactome: R-HSA-418594Reactome: R-HSA-6783783 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-C-C Motif Chemokine 20 antibodyAnti-Beta-Chemokine Exodus-1 antibodyAnti-Cc Chemokine Larc antibodyAnti-Liver And Activation-Regulated Chemokine antibodyAnti-Macrophage Inflammatory Protein 3 Alpha antibodyAnti-Mip-3-Alpha antibodyAnti-Small-Inducible Cytokine A20 Cleaved Into - Ccl20(1-67 - Ccl20(1-64 - Ccl20(2-70 antibodyAnti-CCL20 antibodyAnti-LARC antibodyAnti-MIP3A antibodyAnti-SCYA20 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
